Using the calculated column type in Vista, it is possible to do simple functions like sum, average, etc. But did you know that you can also do a complex formula, like dropping the lowest quiz grade, then averaging?
Using the tools in Vista, create the following formula:
(SUM{column1, column2, column3, columnX} - MIN{column1, column2, column3, columnX})/Y
Note: X is an arbitrary number meaning that you can use however many columns exist in your Grade Book, or however you like. Y is the total number of columns that you are using in your formula (this creates the average)